Set up email using the iOS Mail app
Set up an Office 365, Exchange, or Outlook.com email in the iOS Mail app
Go to your iPhone or iPad's Settings > scroll down and tap Accounts & Passwords > Add Account.
Note: If you're on iOS 10, go to Mail > Accounts > Add Account.


Select Exchange.

Enter your Office 365, Exchange, or Outlook.com email address and a description of your account. Tap Next.

Tap Sign In.

Enter the password associated with your email account. Tap Sign in or Next.

The Mail app may request certain permissions. Tap Accept.

Choose the services you want to sync with your iOS device and tap Save. You're done!

If you have to configure the server settings manually, see below.
Server Settings for Office 365 for business
Use smtp.office365.com for outgoing SMTP server settings.
Incoming Port 993 for IMAP or 995 for POP.
Outgoing Port Number 587.